Dependence of pKa's on Conformational Changes of Glu242 Residue in Bovine CcO
Popovic & Stuchebrukhov, PPS, 5, 611 (2006)
The objectives of this work is to answer the following questions: How do the presence or absence of a proton on the Glu242 and/or His291 site affect the pKa values of the other partner? How do conformational changes of theGlu242 side chain affect the pKa values of the two residues in different redox states of the enzyme? What is the coupling between the redox states of heme a or CuB center and the protonation states of Glu242 and His291 residues? How do the redox state and redox potential of heme a depend on the protonation state ofGlu242, and vice versa?
The two conformations of Glu242 side chain Water chain between Glu242 and PRD of heme a3