Stuchebrukhov research group           Department of Chemistry           University of California at Davis












Cytochrome c Oxidase

To the left is a rendition of chains A and B of bovine heart cytochrome c oxidase. (2OCC in the protein data bank)

Cyan marks the K-channel. These residues also mediate proton uptake.

The orange residue in the center of the figure is Glu242. It is responsible for shuttling protons to the catalytic center of the enzyme.

Green residues mark the Cu_A site. This is the electron acceptor of the enzyme.

The blue molecule is Heme a₃. The yellow residues are the ligands of Cu_B. This is the catalytic site of the enzyme. The CuB atom and the Fe atom of Heme a₃ make up the so-called binuclear center.